… or you are asking an irrelevant question.

Professional Workflows

Depending on the Profession in question, HR or Operations or Manager
or Teacher and their previous exposure to Software will give you a
rough idea of what to expect.

You can go with any of Bootstrap, Foundation, Material UI based
frameworks here.

If you are dealing with Engineers and Designers a no non-sense
workspace driven approach should be the way to go.

The key word you are looking for here is efficient.

Users

You can go with any of Bootstrap, Foundation based frameworks here.
Take time to work on the look and feel by changing the colours.

The key word you are looking for here is productive.

Consumers and Readers

Don’t use a framework. Take time to work on the look and feel using
pure sass driven approaches.

You can use visual story telling here.

The key word you are looking for here is fun and insightful.

Artists

Something insane. Go crazy with WebGL !

Programmers

Something geeky and bare bones.